Studies on Moenomycin (Flavophospholipol)—II

Phosphoglycerate, a building block of moenomycin.

The antibiotic moenomycin(Flavomycin®)1'2'3) isolated from Streptomyces bambergiensis and other strains is a surface-active phosphorus-containing glycolipid that contains an UV-chromophore, 2-amino-cyclopentane-dione-l,34), a lipid portion, moeno cinol5) a carbohydrate moiety6) consisting of several sugars (D-glucose, D-glucosamine, D-quinovosamine), and phosphorus linked in ester form. The pre...

A streamlined metabolic pathway for the biosynthesis of moenomycin A.

Moenomycin A (MmA) is a member of the phosphoglycolipid family of antibiotics, which are the only natural products known to directly target the extracellular peptidoglycan glycosyltransferases involved in bacterial cell wall biosynthesis. The structural and biological uniqueness of MmA make it an attractive starting point for the development of new antibacterial drugs. In order both to elucidat...

Aggregation Behavior of the Antibiotic Moenomycin A in Aqueous Solution

The aggregation behavior of the antibiotic moenomycin A (MoA) in aqueous solution under the influence of pH and ionic strength has been investigated using the fluorescent probe pyrene. Changes of the cmc between 0.03 and 0.7 mM correlate with the effective charge of MoA originating from three ionizable groups, the pKa of which have been determined by infrared spectroscopy. The dependence of the...

Antibacterial activity of synthetic analogues based on the disaccharide structure of moenomycin, an inhibitor of bacterial transglycosylase.

Moenomycin is a natural product glycolipid that inhibits the growth of a broad spectrum of Gram-positive bacteria. In Escherichia coli, moenomycin inhibits peptidoglycan synthesis at the transglycosylation stage, causes accumulation of cell-wall intermediates, and leads to lysis and cell death. However, unlike Esc. coli, where 5-6 log units of killing are observed, 0-2 log units of killing occu...

Germination studies on pistacia terebinthus